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Hoeksema H.,Vandekerckhove D., Verbelen J., Heyneman A., Monstrey S.

A comparative study of 1% silver sulphadiazine (Flammazine®) versus an enzyme alginogel (Flaminal®) in the treatment of partial thickness burns
Burns 2013; 1234-1241

Introduction: In the conservative treatment of burns, rapid wound healing is desirable to obtain good a esthetic and functional results. The aim of this study was to compare the efficacy of 1% Silversulfadiazine (SSD/Flammazine1) and an enzyme alginogel (Flaminal1or Flaminal1 Forte) on the healing of superficial and intermediate partial thickness burns.

Methods: In this retrospective cohort study comparable burn wounds treated with Flaminal1 or with 1% SSD were included. Outcome parameters included: length of hospital stay, bacterial burden and time to wound closure. Significance was tested using SPSS package.

Results: 44 wounds in the Flaminal1 group, and 39 wounds in the 1% SSD group were included. Wounds treated with Flaminal1 showed a significantly higher bacterial load ( p = 0.024) and contained significantly more bacterial species ( p = 0.010) but showed a significantly shorter healing time of 17 vs. 24 days ( p < 0.0001).

Conclusion: A significantly shorter healing time was demonstrated in partial thickness burn wounds treated with Flaminal1 versus 1% SSD, which may lead to a shorter length of hospital stay and better scar quality. The possibility of accurate burn depth assessment and the results in this study corroborate the change in treatment protocol made in the year 2000 when we switched from 1% SSD to Flaminal1.

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